Available Technology

Coacervate Microparticles Useful for the Sustained Release Administration of Therapeutic Agents

Polymer matrix-based sustained-release formulations have gained significant interest in recent years for both parenteral and delivery of small molecules as well as proteins and other biological molecules. Compared to conventional dosage forms, these delivery systems offer improved efficacy, reduced toxicity, convenience and improved patient compliance. Colloidal carriers such as microparticles are considered a promising approach for targeting drugs to specific organs that could permit the sustained release at the target site and reduce potential side effects. Matrix-structured microparticles that are formed by coacervation are desirable since they permit therapeutic agents to become incorporated into the microparticles under mild conditions (e.g. delivery of nucleic acids).
Benefits: 
Enhanced efficacy of therapeutic agents -Reduced toxicity of therapeutic agents -Improved patient compliance
applications: 
Inventors: 
Phillip Heller
Internal Laboratory Ref #: 
E-116-2004/0
Lab Representatives
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