available technology

4G10, a Monoclonal Antibody Against the Chemokine Receptor CXCR4, Raised Against a Synthetic Peptide of 38 Residues in Length Derived from the N-terminal Sequence of CXCR4

This invention identifies a monoclonal antibody (4G10) against the chemokine receptor CXCR4 and is a mouse IgG1 antibody. CXCR4 has been identified as a co-receptor mediating entry of HIV-1 into T cells. Subsequently, CXCR4 has been implicated in normal physiological functions, including activation...
available technology

A Full-Length Infectious cDNA Clone of Zika Virus from the 2015 Epidemic in Brazil as a Genetic Platform for Studies of Virus-Host Interactions and Vaccine Development

An arthropod-borne virus, Zika virus (ZIKV), has recently emerged as a major human pathogen. Associated with complications during perinatal development and Guillain-Barré syndrome in adults, ZIKV raises new challenges for understanding the molecular determinants of flavivirus pathogenesis. This...
available technology

A Novel Fusion Protein for Inhibiting HIV Budding

Ubiquitin plays a critical role in HIV-1 budding. Vectors containing deubiquitin enzymes (DUbs) were constructed to deliver DUbs to HIV-1 production sites in living cells. The DUbs vectors comprise DUb cDNAs and cDNA expressing either HIV-1 gag, or the ESCRT protein TSG101. Experimental data show...
available technology

A Novel Fusion Protein for Inhibiting HIV Budding

Ubiquitin plays a critical role in HIV-1 budding. Vectors containing deubiquitin enzymes (DUbs) were constructed to deliver DUbs to HIV-1 production sites in living cells. The DUbs vectors comprise DUb cDNAs and cDNA expressing either HIV-1 gag, or the ESCRT protein TSG101. Experimental data show...

Pages