Success Story

Tin-117m Radionuclide Production and Medical Use

Brookhaven National Laboratory has a long history of working with radioisotopes for medical applications. One radionuclide in particular, Tin-117m (117mSn), has unique properties permitting its dual use for imaging and for treatment of various medical conditions. Its first application was as a palliative treatment of bone pain resulting from cancer metastases. For various reasons, this application did not come to fruition as an available treatment. However, this did not deter Dr. Suresh Srivastava’s interests in continuing to develop the use of the material. Nor did it dissuade Dr. Gilbert Gonzales of Clear Vascular, Inc. from continuing his interactions with Brookhaven. The collaboration between Dr. Srivastava and Dr. Gonzales, which began over a decade ago, has now become a business arrangement in which Clear Vascular, Inc. and Brookhaven Science Associates, LLC. (“BSA”), contractor/operator of Brookhaven National Laboratory, have entered into an Exclusive Field of Use License Agreement for Cardiovascular uses of tin-117m.

The license agreement results from a fruitful interaction between Clear Vascular and Brookhaven National Laboratory under the Initiative for Proliferation Prevention (“IPP”) CRADA program. In 2003 Clear Vascular and BSA executed the IPP CRADA that enabled the team to work in Russia to transfer the production technology for tin-117m from a nuclear reactor method to linear accelerator methods. The new methods create greater quantities and higher specific activity tin-117m than was previously practical. The work resulted in four patents for the production of high specific activity tin-117m using a linear accelerator rather than a nuclear reactor. The increased availability of the tin radionuclide is sufficient to support the production of medically useful materials for treatments of cardiovascular conditions.

Clear Vascular has completed phase two clinical imaging trials and will be starting studies on therapeutic treatment s of heart disease.