The UC Davis/NIH NeuroMab Facility

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The mission of the UC Davis/NIH NeuroMab facility is to generate and distribute high quality, validated mouse monoclonal antibodies against molecular targets found in the nervous system (NeuroMabs). These antibodies are suitable for 1) immunocytochemical-based imaging studies of protein localization in adult, developing and pathological brain samples, 2) biochemical analyses of subunit composition and post-translational modifications of native brain proteins, and 3) proteomic analyses of native brain protein networks. The NeuroMab facility is funded for a five-year period with the goal of making 200-300 monoclonal antibodies against neuronal proteins. An initial emphasis has been to select membrane proteins (receptors/channels/transporters), synaptic proteins, other neuronal signaling molecules, and proteins with established links to disease states as targets. Recently, the NeuroMab facility was expanded to include targets involved in neurodevelopment and in epigenetic events. The resulting monoclonal antibodies (NeuroMabs) are produced on a large scale and made available to the neuroscience research community at low cost in the form of tissue culture supernatant and purified immunoglobulin.

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