The Experimental Therapeutics and Pathophysiology Branch (ETPB)

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The overarching goals of the current (ETPB) are: (1) to provide administrative support for our Section (SNMD); (2) to maintain a common screening program for the Division of Intramural Research Program (DIRP) studies on mood and anxiety disorders; and (3) to support clinical and research training. The Screening Program (01-M-0254) provides oversight, training, and quality control of administration of a range of structured diagnostic and dimensional measures of psychopathology. Aside from extensive clinical measures, the major data components that are centralized in the program include: (1) CTDB-Clinical trials database; (2) BioBNK that contains a diverse set of biologic measures; and (3) MAP-R (Mood and Anxiety Disorders Repository protocol) of neuroimaging data. The clinical measures collected include comprehensive diagnostic interviews including history of suicide attempts and ideation, stress/trauma, sleep problems, temperament, psychosis, medical conditions, as well as dimensional measures of the core features of mood and related disorders including positive and negative affect, arousal/regulatory systems and cognitive function.

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