There are an estimated 1 to 2 million invasive brown treesnakes on Guam. They cause untenable damage to Guam’s natural and human resources. USDA Wildlife Services in cooperation with the Government of Guam, DOI Office of Insular Affairs, Department of Defense, and Applied Design Corp (Boulder, CO) deployed the first automated aerial baiting system to reduce populations of the arboreal brown treesnakes on Guam. The technique delivers acetaminophen-treated dead mice into the forest canopy. The aerial delivery of bait is critical to the control of snakes in remote areas, enabling the restoration of Guam ecosystems and reintroduction of native species.