A National Institutes of Health technology pertains to conjugate polypeptide compositions that are designed to elicit antibody response against HIV. The peptides are conjugates of one gp41 capable of forming a stable coiledcoil structure and another gp41 capable of forming an alpha-helical structure. These structural elements of gp41 were identified as important for playing a role in HIV-1 cell entry. Compositions that elicit neutralizing antibodies against HIV have been elusive to date, but the subject technology may be important in realizing that goal.
Applications include HIV vaccines and neutralizing antibodies against HIV
More info: Susan Ano, Ph.D.; 301-435-5515; anos@mail.nih.gov
